The relationship between glucose metabolism, insulin sensitivity and obesity
Obesity is a triggering factor for diabetes associated with insulin resistance. In individuals who are obese, higher amounts of non-esterified fatty acids, glycerol, hormones, and pro-inflammatory cytokines that could participate in the development of insulin resistance are released by adipose tissue.
Obesity leads to ectopic fat storage and an increase in FA metabolites that inhibit insulin signaling through activation of PKC in liver and muscle.
Visceral fat makes chemicals and hormones that can be toxic to the body. Visceral fat produces more of these toxic substances than subcutaneous fat, so it can be more harmful to your health. Because of this, visceral fat carries a range of health risks for everyone.
Mechanism• Palmitoleic acid (POA) levels increase during obesity. It counters glucotoxicity and elevated saturated fat burden. During obesity POA rescues the obesity associated lipotoxicity.
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